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This paper presents an integrative analysis framework combining natural hazards with network mobility to provide insights on disaster preparedness and relief. In particular, this framework characterizes the impact of seismically induced landslides on network mobility to reveal the mobility changes immediately after the events and throughout the course of restoration and recovery efforts. Landslides not only undermine the structural integrity of roadways, but also deposit a significant amount of material on the road surface, usually resulting in partial or complete road closure to traffic. The highly populated Portland, Oregon, Metro is selected as a case study to demonstrate this framework given that the Pacific Northwest is highly prone to large earthquakes as part of the Cascadia Subduction Zone as well as highly susceptible to landslides given its high topographic relief and wet climate. In this case study, travel time to the west and east sides of Willamette River, which divides the Portland Metro area, shows an abrupt change in mobility. In particular, the Portland Hills region with its steep topography is identified as the most vulnerable region. Based on a temporal analysis of recovery, the majority of the network mobility is expected to be restored after 30 days. The results of this study serve as a preliminary assessment of the impact of landslides on network mobility and can facilitate decision making in emergency planning.